โรคแผลในกระเพาะอาหาร
ยาที่ใช้ในโรคระบบทางเดินอาหาร (Drugs Use for Gastrointestinal diseases)
#rebamipide
Patients with gastric ulcer size 0.5-3 cm
(omeprazole 20 mg OD + rebamipide 100 mg TID)
or PPI monotherapy group (omeprazole 20 mg OD + placebo)
Primary endpoint was healed GU after 4 weeks of treatment determined by follow-up esophagogastroduodenoscopy.
Treatment with rebamipide plus PPI has a trend toward improved GU healing, compared with PPI monotherapy, especially in subgroup of patients with features of difficult to heal GU (presence of H. pylori, atrophic gastritis, intestinal metaplasia, NSAIDs and smoking).
In general, this meta-analysis has presented the crucial profit of rebamipide plus PPIs in managing ESD-induced ulcers. The results of the pooled analysis mainly show that rebamipide plus PPIs is practical for protecting against ESD-induced ulcers at four weeks but not at eight weeks, especially large ulcers (>20 mm). However, more studies with designs of large scale and high quality are still required to further determine the efficacy of rebamipide plus PPIs.
POSTED 2022.01.09
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