LATE is defined by changes in the TDP-43 protein in brain tissue and frequently co-exists with Alzheimer’s disease changes, such as buildup of beta amyloid plaques and tau tangles.
LATE is a prevalent condition in late life and can contribute to memory loss and cognitive decline,
The newly proposed criteria aim to help clinicians better differentiate LATE from Alzheimer’s, ultimately leading to more precise diagnoses and improved treatment strategies.