(Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle)
(That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.)
ผู้นำการวิจัยครั้งนี้คือผู้เชี่ยวชาญชื่อว่า Richard van Breemen ซึ่งทำงานอยู่ที่ Global Hemp Innovation Center (ศูนย์นวัตกรรมกัญชงทั่วโลก) ที่ตั้งอยู่ในรัฐโอเรกอน ประเทศสหรัฐฯ อเมริกา โดยเขาได้ออกมาแสดงความเห็นในเรื่องนี้ว่า
(These compounds can be taken orally and have a long history of safe use in humans, They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers.)
(These cannabinoid acids are abundant in hemp and in many hemp extracts, They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans.)
Van Breemen กล่าวเสริมอีกว่าผลการวิจัยยังแสดงให้เห็นว่าสาร cannabinoids นั้นมีประสิทธิภาพในการป้องกันสายพันธุ์ใหม่ ๆ ซึ่งมีความสามารถในการหลบหลีกภูมิคุ้มกันจากวัคซีน
(These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen, Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.)
(our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.)
(Resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2.)